4 months ago
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An Athlete Squatted 500 Reps In 20 Minutes. This Is What Happened To His Kidneys.

#biology #science #genetics #doctor #Education
This patient presented to an emergency room in Illinois, 2010
Dr. Pavlos Msaouel, MD, PhD is a leading physician-scientist researching this space. See his publications in references below.
Music by Lifeformed ► https://www.youtube.com/watch?v=FxJXn...
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A Student Ate Gas Station Sushi For Breakfast. This Is What Happened To His Stomach. ► https://youtu.be/HtZi7nj-WYw
A Mom Tried Keto Diet For 30 Days. This Is What Happened When Things Went Wrong. ► https://youtu.be/W74jOR9V6UA
Is Alkaline Water Really Better For You? ► https://youtu.be/1CBE-5Ot4jU
Nephrology (Renal Playlist) ► https://www.youtube.com/watch?v=Ioir8....
Individuals with sickle cell disease are homozygotes of the sickle gene. This is a genetic mutation that developed on the beta chain of red blood cell hemoglobin, that is protective of malaria, endemic in equatorial Africa, where the mutation is currently known to have originated from. It follows Mendelian inheritance. Sickling will cause pain, anemia, chronic tiredness, and kidney damage, among others.
Sickle cell trait refers to heterozygosity. In trait, the RBC's don't typically sickle in the body, but they will in places that are particularly hypertonic and hypoxic. The foremost example of that type of environment, is the kidney medulla. Hypertonicity and hypoxia are favored in this tissue because of its function in water reabsorption in the Loop of Henle. The descending loop into the inner medulla is permeable to water only. As more water flows out into the medulla, it becomes dilute. In the ascending limb of the Loop of Henle, ions can be pumped out of the filtrate and in to the medulla, maintaining hypertonicity of the tissue, allowing more water to be reabsorbed.
In the vasa recta, the RBC's will sickle into the medulla, causing vaso-occlusion. Meaning the mechanisms of maintaining medulla hypertonicity will be compromised, turning hypoxia to become anoxia (pO2 = 0). This damage will force all filtrate to become urine, so water loss will ensue.
In extreme exercise, this will cause hemoconcentration, hypoxemia, worsening lactic acidosis, and increased sickling.
Images are used with license
- "Ultrasonography of the Kidney" Diagnostics 6 (1): 2.
- RMC CT Case Rep Oncol Med. 2014;2014:615895.
- CT courtesy A.Prof Frank Gaillard, Radiopaedia.org, rID: 10650
References, [0] Msaouel, P, et. al. A Model Linking Sickle Cell Hemoglobinopathies and SMARCB1 Loss in Renal Medullary Carcinoma. Clin Cancer Res. 2018 May 1;24(9):2044-2049. PMID 29440190
[1] Msaouel, P, et. al. Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma. Clin Genitourin Cancer. 2019 Feb;17(1):1-6..
[2] Clinical manifestations and diagnosis of rhabdomyolysis. UpToDate.
[3] Clinical features and diagnosis of heme pigment-induced acute kidney injury. UpToDate.
[4] Errors in ultrasonographic measurements of the kidney. Nephrol Dial Transplant 2000;15:549–50.
[5] The variant renal and suprarenal blood supply with data on the interior phrenic, ureteral and gonadal arteries: a statistical analysis based on 185 dissections and a review of the literature. J Int Coll Surg 1958;29:41–76.
[6] Bird, Stewart, Lightfoot. Transport Phenomena. 2007.
[7] G Hagen, Ann Phys Chem, 46, 423-442. (1839).
[8] E Hagenbach, Pogg. Annalen der Physik u. Chemie, 108, 385-426 (1860).
[9] Lancet. 2010;376(9757):2018. PMID: 21131035
[10] Mortality and morbidity in Jamaican adults with sickle-cell trait and with normal haemoglobin followed up for twelve years. Lancet. 1976;2(7989):784. PMID: 61453
[11] Age and prevalence of sickle-cell trait in a large ambulatory population. Genet Epidemiol. 1987;4(4):307. PMID: 3666437
[12] Vander’s Renal Physiology, 9e
[13] Hypoxia of the renal medulla--its implications for disease. N Engl J Med 1995;332:647–55.
[14] Renal medullary circulation: hormonal control. Kidney Int. 1990 Jan;37(1):1-13. PMID 2137185
[15] Compartment syndrome and fatal rhabdomyolysis in sickle cell trait.
WMJ. 2005 Aug;104(6):67-71. PMID 16218320
[16] Acute compartment syndrome of the extremities. UpToDate.
[17] Myoglobinuria, rhabdomyolysis and marathon running. Q J Med. 1978;47(188):463. PMID 751088
[18] DNA damage and osmotic regulation in the kidney. Am J Physiol Renal Physiol. 2005 Jul;289(1):F2-7. PMID 15951478
[19] Chromosomal translocations and palindromic AT-rich repeats. Curr Opin Genet Dev. 2012 Jun; 22(3): 221–228.
These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your own physician in person for that.
#medicine #science

#sickle cell #genes #medicine #scientist

Chubbyemu photo 1 An Athlete Squatted 500 Reps... Chubbyemu photo 2 An Athlete Squatted 500 Reps... Chubbyemu photo 3 An Athlete Squatted 500 Reps... Chubbyemu photo 4 An Athlete Squatted 500 Reps...

CC's on ✅

by Chubbyemu 4 months ago

A man watched 50 chubbyemu videos in a day. This is what happened to his anxiety.

by Alterinq 4 months ago

The moral of this story: Don't do more than 499 squat reps in 20 minutes.

by L. Ron Gardner 2 months ago

“Before his workout he complained that his urine was red”

Thaaaats a pretty clear sign to but down the weights and pick up the emergency line

by Regular Sherlock 2 months ago

The common theme in all these videos seems to be “everything in moderation” lol

by Chris Ibsen 3 weeks ago

My guy worked out so hard that he dissolved his own muscles. Sounds like some anime shit

by DashFlash 1 month ago

What I've learned from this channel: Literally everything will kill you.

Also, -emia means "presence in blood"

by Onyx1916 4 months ago

Pees blood in the morning

This dude: that is very much adequate

by Luigi fan 1 month ago

rip to this young man he just wanted to do better an overcome instead of being depressed

by trusty davis 1 month ago

"He said his urine that morning was red"
"He wouldn't go low enough on his squats, he struggled, collapsed"
"Teammates thought he was joking until he started shaking"

A dude gives you all these warning signs and you think he was joking? Dang

by Juan Pablo Robayo 1 month ago

These videos make me realise how fragile we humans are.

by Quincey Brown 1 month ago

Me: Steps onto treadmill

Hears Chubbyemu music

Me: Steps off treadmill immediately

by Onyx1916 4 months ago

I feel like people are forgetting that these were real events happening to a real person, who died young and very unexpectedly. It must have been terrifying. I am so sorry he died and I feel for the family that lost him. KG, rest in peace. I'm sorry your death had to be shared this way.

by Mae 1 month ago

This one was so sad. He was just trying to push himself as an athlete. :-(

by M J 1 month ago

Video: his legs dissolved
Music: 🧚‍♀️🌲🌱🌸

by Rittle Tittle 4 weeks ago

When you wanna train like an Anime Protagonist, but you have the genes of a side character.

~RIP my friend💐🍀~

by The Sophisticated Tarzan 1 month ago

I'm really happy that you included a case which discusses sickle cell disease. There are still a lot of misconceptions about it today and this video was very descriptive.

by ivyofskies 4 months ago

A student devoted his life to only getting A+ and dipped bellow a B. This is what happened to his emotional health.

by Sunquad 2 months ago

This is why it’s important to have a good strength and conditioning coach. Even when you’re doing off season / solo workouts . My highs school football coach would write up our workouts even when we came in for 5 am solo training. Most the time we were doing the appropriate weight, resting properly, and taking the supplements our body needed to recover. Having that strength coach helping us understand the proper way to train not only made us stronger and faster ... it kept us healthy. This video is sad man....

by jaybuckODT21 1 month ago

This is really sad and disappointing, someone so driven getting put down by their own drive.

by J Sensei 1 month ago

Mp3 Download

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